Redesign of a cross-reactive antibody to dengue virus with broad-spectrum activity and increased in vivo potency

Redesign of a cross-reactive antibody to dengue virus with broad-spectrum activity and increased in vivo potency

Affinity improvement of proteins, including antibodies, by computational chemistry broadly relies on physics-based energy functions coupled with refinement. However, achieving significant enhancement of binding affinity (>10-fold) remains a challenging exercise, particularly for cross-reactive an...

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Main Authors: Raguram, S. (Author), Sasisekharan, V. (Author), Tharakaraman, Kannan (Contributor), Robinson, Luke Nathaniel (Contributor), Hatas, Andrew (Contributor), Chen, Yiling (Contributor), Sasisekharan, Ram (Contributor), Siyue, Liu (Author), Wogan, Gerald N (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. School of Engineering (Contributor), Singapore-MIT Alliance in Research and Technology (SMART) (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Wogan, Gerald N. (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2013-12-30T17:17:23Z.
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