Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system

Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system

Technologies allowing for specific regulation of endogenous genes are valuable for the study of gene functions and have great potential in therapeutics. We created the CRISPR-on system, a two-component transcriptional activator consisting of a nuclease-dead Cas9 (dCas9) protein fused with a transcri...

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Bibliographic Details
Main Authors: Wang, Haoyi (Author), Yang, Hui (Author), Shi, Linyu (Author), Katz, Yarden (Contributor), Theunissen, Thorold W (Author), Rangarajan, Sudharshan (Author), Jaenisch, Rudolf (Contributor), Shivalila, Chikdu Shakti (Contributor), Dadon, Daniel Benjamin (Contributor), Cheng, Albert Wu (Author)
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Whitehead Institute for Biomedical Research (Contributor), Cheng, Albert W. (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2014-01-31T19:44:23Z.
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