Identification of small molecules for human hepatocyte expansion and iPS differentiation

Identification of small molecules for human hepatocyte expansion and iPS differentiation

Cell-based therapies hold the potential to alleviate the growing burden of liver diseases. Such therapies require human hepatocytes, which, within the stromal context of the liver, are capable of many rounds of replication. However, this ability is lost ex vivo, and human hepatocyte sourcing has lim...

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Main Authors: Shan, Jing (Contributor), Ross, Nathan T. (Author), Logan, David J. (Author), Thomas, David (Author), Duncan, Stephen A. (Author), North, Trista E. (Author), Goessling, Wolfram (Author), Carpenter, Anne E. (Author), Schwartz, Robert E. (Author), Bhatia, Sangeeta N (Author)
Other Authors: Whitaker College of Health Sciences and Technology (Contributor), Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Schwartz, Robert (Contributor), Bhatia, Sangeeta N. (Contributor)
Format: Article
Language:English
Published: 2014-04-11T17:04:24Z.
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