Hidden dimensions in protein evolution: stability, mutational robustness, and evolvability
Proteins are evolvable in the sense that they are readily able to acquire new or improved functions through the process of mutation and selection. Here, I examine what properties influence the ability of proteins to evolve new functions. I show that proteins with similar biochemical properties can...
Internet
https://thesis.library.caltech.edu/1984/1/bloom_thesis.pdfBloom, Jesse D. (2007) Hidden dimensions in protein evolution: stability, mutational robustness, and evolvability. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/3MNT-7W93. https://resolver.caltech.edu/CaltechETD:etd-05232007-094635 <https://resolver.caltech.edu/CaltechETD:etd-05232007-094635>