Anticancer Activities of Resveratrol Alone and in Combination with Ascorbic Acid

Anticancer Activities of Resveratrol Alone and in Combination with Ascorbic Acid

Bibliographic Details
Main Author: Zhang, Huiying
Language:English
Published: Kent State University / OhioLINK 2010
Subjects:
Biochemistry
Pharmaceuticals
Pharmacology
resveratrol
ascorbate
combination therapy
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=kent1271693335
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-kent12716933352021-08-03T05:37:07Z Anticancer Activities of Resveratrol Alone and in Combination with Ascorbic Acid Zhang, Huiying Biochemistry Pharmaceuticals Pharmacology resveratrol ascorbate combination therapy Resveratrol, a naturally occurring polyphenol found in grapevines and other plants, has been shown to have anti-cancer, anti-viral, and other activities. The specific aim of this thesis research was to evaluate and compare the antitumor activities of resveratrol alone and in combination with ascorbate against a panel of two human tumor cell lines (DU145 and MDAH) using a micro-tetrazolium (MTT) assay. Triplicate samples were assayed 12, 24, 48, and 72 hours after continuous treatments, with twelve concentrations of resveratrol and three or five combination ratios tested per time point. The FIC index, which is a marker of synergism, was calculated. Results indicated that resveratrol and ascorbate acted synergistically, reducing the time and concentrations of each component necessary to achieve an effective cytotoxicity level in hormone-independent cancer cell lines. The systematic studies and analyses of resveratrol-ascorbate combinations presented in this study have clinical significance for the evaluation and development of combination chemotherapy for the treatment of various cancer diseases. 2010-04-22 English text Kent State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=kent1271693335 http://rave.ohiolink.edu/etdc/view?acc_num=kent1271693335 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Biochemistry
Pharmaceuticals
Pharmacology
resveratrol
ascorbate
combination therapy
spellingShingle Biochemistry
Pharmaceuticals
Pharmacology
resveratrol
ascorbate
combination therapy
Zhang, Huiying
Anticancer Activities of Resveratrol Alone and in Combination with Ascorbic Acid
author Zhang, Huiying
author_facet Zhang, Huiying
author_sort Zhang, Huiying
title Anticancer Activities of Resveratrol Alone and in Combination with Ascorbic Acid
title_short Anticancer Activities of Resveratrol Alone and in Combination with Ascorbic Acid
title_full Anticancer Activities of Resveratrol Alone and in Combination with Ascorbic Acid
title_fullStr Anticancer Activities of Resveratrol Alone and in Combination with Ascorbic Acid
title_full_unstemmed Anticancer Activities of Resveratrol Alone and in Combination with Ascorbic Acid
title_sort anticancer activities of resveratrol alone and in combination with ascorbic acid
publisher Kent State University / OhioLINK
publishDate 2010
url http://rave.ohiolink.edu/etdc/view?acc_num=kent1271693335
work_keys_str_mv AT zhanghuiying anticanceractivitiesofresveratrolaloneandincombinationwithascorbicacid
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