Investigating and engineering the substrate specificity of DNA methyltransferases

DNA methyltransferases catalyse the transfer of methyl groups from the cofactor <i>S</i>-adenosyl-L-methionine to a target base (adenine or cytosine) within a cognate recognition sequence. I have studied cofactor binding, DNA specificity and the role of conserved amino acid motifs in the...

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Bibliographic Details
Main Author: Cohen, H.
Published: University of Cambridge 2003
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597811