GENOTYPIC AND EXPRESSION ANALYSIS OF CYP3A4 AND CYP3A5 IN PATIENTS WITH CHRONIC MYELOID LEUKAEMIA
Chronic myeloid leukaemia (CML) is a haematological malignancy characterised by the BCR-ABL fusion oncogene which encodes for a constitutively active tyrosine kinase. Imatinib mesylate is a tyrosine kinase inhibitor that has effectively been used in the treatment of CML. However, some individuals ex...
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Others |
| Language: | en-uk |
| Published: |
University of the Free State
2013
|
| Subjects: | |
| Online Access: | http://etd.uovs.ac.za//theses/available/etd-11202013-151617/restricted/ |