Úloha tukové tkáně a jejích produktů při rozvoji inzulínové rezistence a systémové zánětlivé reakce
Hyperglycemia and insulin resistance are tightly interconnected pathophysiological conditions that increase the risk for development of cardiovascular diseases. Our current knowledge indicates that one of important reasons leading to the development of insulin resistance could lies in a dysfunction...
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2009
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Online Access: | http://www.nusl.cz/ntk/nusl-278708 |
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ndltd-nusl.cz-oai-invenio.nusl.cz-2787082018-10-03T04:29:21Z Úloha tukové tkáně a jejích produktů při rozvoji inzulínové rezistence a systémové zánětlivé reakce Adipose tissue and its role in development of insulin resistance and systemic inflammatory reaction Roubíček, Tomáš Haluzík, Martin Stárka, Luboslav Housa, Daniel Hyperglycemia and insulin resistance are tightly interconnected pathophysiological conditions that increase the risk for development of cardiovascular diseases. Our current knowledge indicates that one of important reasons leading to the development of insulin resistance could lies in a dysfunction of adipose tissue with subsequent ectopic lipids accumulation in muscles and liver. Adipose tissue represents the main body storage site of energy. Furthermore, adipose tissue is also an active endocrine organ producing numerous biologically active molecules, e.g. cytokines, proinflammatory or to a lesser degree anti-inflammatory factors or components of the renin-angiotensin-aldosterone system. Some of the components of the local renin-angiotensin-aldosterone system produced by the adipose tissue can directly induce local insulin resistance within the adipose tissue. Hyperglycemia and insulin resistance are also common in critically ill patients and exaggeration of insulin resistance in these patients is accompanied by increased morbidity and mortality. Our previous study has demonstrated that adipose tissue plays an important role in the development of hyperglycemia and insulin resistance in critically ill patients by production of numerous proinflammatory cytokines. First part of this dissertation thesis is... 2009 info:eu-repo/semantics/doctoralThesis http://www.nusl.cz/ntk/nusl-278708 cze info:eu-repo/semantics/restrictedAccess |
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Czech |
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Doctoral Thesis |
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NDLTD |
description |
Hyperglycemia and insulin resistance are tightly interconnected pathophysiological conditions that increase the risk for development of cardiovascular diseases. Our current knowledge indicates that one of important reasons leading to the development of insulin resistance could lies in a dysfunction of adipose tissue with subsequent ectopic lipids accumulation in muscles and liver. Adipose tissue represents the main body storage site of energy. Furthermore, adipose tissue is also an active endocrine organ producing numerous biologically active molecules, e.g. cytokines, proinflammatory or to a lesser degree anti-inflammatory factors or components of the renin-angiotensin-aldosterone system. Some of the components of the local renin-angiotensin-aldosterone system produced by the adipose tissue can directly induce local insulin resistance within the adipose tissue. Hyperglycemia and insulin resistance are also common in critically ill patients and exaggeration of insulin resistance in these patients is accompanied by increased morbidity and mortality. Our previous study has demonstrated that adipose tissue plays an important role in the development of hyperglycemia and insulin resistance in critically ill patients by production of numerous proinflammatory cytokines. First part of this dissertation thesis is... |
author2 |
Haluzík, Martin |
author_facet |
Haluzík, Martin Roubíček, Tomáš |
author |
Roubíček, Tomáš |
spellingShingle |
Roubíček, Tomáš Úloha tukové tkáně a jejích produktů při rozvoji inzulínové rezistence a systémové zánětlivé reakce |
author_sort |
Roubíček, Tomáš |
title |
Úloha tukové tkáně a jejích produktů při rozvoji inzulínové rezistence a systémové zánětlivé reakce |
title_short |
Úloha tukové tkáně a jejích produktů při rozvoji inzulínové rezistence a systémové zánětlivé reakce |
title_full |
Úloha tukové tkáně a jejích produktů při rozvoji inzulínové rezistence a systémové zánětlivé reakce |
title_fullStr |
Úloha tukové tkáně a jejích produktů při rozvoji inzulínové rezistence a systémové zánětlivé reakce |
title_full_unstemmed |
Úloha tukové tkáně a jejích produktů při rozvoji inzulínové rezistence a systémové zánětlivé reakce |
title_sort |
úloha tukové tkáně a jejích produktů při rozvoji inzulínové rezistence a systémové zánětlivé reakce |
publishDate |
2009 |
url |
http://www.nusl.cz/ntk/nusl-278708 |
work_keys_str_mv |
AT roubicektomas ulohatukovetkaneajejichproduktuprirozvojiinzulinoverezistenceasystemovezanetlivereakce AT roubicektomas adiposetissueanditsroleindevelopmentofinsulinresistanceandsystemicinflammatoryreaction |
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1718758820348428288 |