Apathy as a Treatment Target in Alzheimer's Disease: Implications for Clinical Trials

Apathy as a Treatment Target in Alzheimer's Disease: Implications for Clinical Trials

Apathy is one of the most prevalent, stable and persistent neuropsychiatric symptom across the neurocognitive disorders spectrum. Recent advances in understanding of phenomenology, neurobiology and intervention trials highlight apathy as an important target for clinical intervention. We conducted a...

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Bibliographic Details
Main Authors: Adler, L. (Author), Agüera-Ortiz, L. (Author), Bateman, D.R (Author), Brodaty, H. (Author), Cantillon, M. (Author), for the ISTAART NPS PIA (Author), Geda, Y.E (Author), Ismail, Z. (Author), Lanctôt, K.L (Author), Marshall, G.A (Author), Mortby, M.E (Author), Padala, P.R (Author), Politis, A. (Author), Rosenberg, P.B (Author), Siarkos, K. (Author), Sultzer, D.L (Author), Theleritis, C. (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2022
Subjects:
agomelatine
Alzheimer disease
Alzheimer Disease
amfebutamone
amyloid beta protein
antidepressant agent
apathy
Apathy
art therapy
Article
assessment
atypical antipsychotic agent
behavior therapy
biological marker
Biomarkers
brain atrophy
brain cortex
cholinesterase inhibitor
clinical assessment
clinical effectiveness
clinical trial (topic)
cognition
cognitive behavioral therapy
dementia
depression
diagnostic procedure
disorders of higher cerebral function
donepezil
escitalopram
evaluation study
evidence based practice
future directions
human
Humans
ISTAART neuropsychiatric syndromes professional interest area
mechanisms and biomarkers
mental disease
metabolism
methylphenidate
music therapy
nerve degeneration
neurocognitive disorders
Neurocognitive Disorders
neurotransmitter
pathogenesis
patient care
perfusion
pre-dementia states
psychology
psychometry
psychosocial intervention
rating scale
repetitive transcranial magnetic stimulation
sensitivity analysis
symptom
tau protein
transcranial direct current stimulation
treatment and intervention
treatment target
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