Transmembrane protein 108 inhibits the proliferation and myelination of oligodendrocyte lineage cells in the corpus callosum

Transmembrane protein 108 inhibits the proliferation and myelination of oligodendrocyte lineage cells in the corpus callosum

Background: Abnormal white matter is a common neurobiological change in bipolar disorder, and dysregulation of myelination in oligodendrocytes (OLs) is the cause. Transmembrane protein 108 (Tmem108), as a susceptible gene of bipolar disorder, is expressed higher in OL lineage cells than any other li...

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Bibliographic Details
Main Authors: Lai, X. (Author), Liao, X. (Author), Ma, C. (Author), Miao, X. (Author), Pan, H. (Author), Wang, S. (Author), Wu, Y. (Author), Yu, J. (Author), Zhang, Y. (Author), Zhong, Y. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
animal
Animals
Bipolar disorder (BD)
cell lineage
Cell Lineage
cell proliferation
Cell Proliferation
corpus callosum
Corpus Callosum
Corpus callosum (CC)
mania
Mania
metabolism
Mice
mouse
myelin sheath
Myelin Sheath
Myelination
Oligodendrocyte (OL)
oligodendroglia
Oligodendroglia
Tmem108
white matter
White Matter
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