Effective connectivity in the default mode network is distinctively disrupted in Alzheimer's disease—A simultaneous resting-state FDG-PET/fMRI study

Effective connectivity in the default mode network is distinctively disrupted in Alzheimer's disease—A simultaneous resting-state FDG-PET/fMRI study

A prominent finding of postmortem and molecular imaging studies on Alzheimer's disease (AD) is the accumulation of neuropathological proteins in brain regions of the default mode network (DMN). Molecular models suggest that the progression of disease proteins depends on the directionality of si...

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Bibliographic Details
Main Authors: Drzezga, A. (Author), Grimmer, T. (Author), Grothe, M.J (Author), Pasquini, L. (Author), Rauschecker, J.P (Author), Riedl, V. (Author), Scherr, M. (Author), Sorg, C. (Author), Tahmasian, M. (Author), Utz, L. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
aged
Aged
Alzheimer disease
Alzheimer Disease
Article
brain cortex
Cerebral Cortex
clinical article
cognitive defect
connectome
Connectome
controlled study
default mode network
Default Mode Network
diagnostic imaging
directional signaling
disease exacerbation
effective connectivity
energy metabolism
female
fluorodeoxyglucose
functional connectivity
functional magnetic resonance imaging
functional neuroimaging
hippocampus
human
Humans
Magnetic Resonance Imaging
male
medial prefrontal cortex
metabolism
multimodal imaging
Multimodal Imaging
nuclear magnetic resonance imaging
parietal cortex
pathophysiology
positron emission tomography
Positron-Emission Tomography
procedures
resting state
signal transduction
simultaneous PET/fMRI
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