White matter hyperintensities induce distal deficits in the connected fibers

White matter hyperintensities (WMH) are common in elderly individuals and cause brain network deficits. However, it is still unclear how the global brain network is affected by the focal WMH. We aimed to investigate the diffusion of WMH-related deficits along the connecting white matters (WM). Brain...

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Bibliographic Details
Main Authors:	Cheng, X. (Author), Ding, D. (Author), Dong, Q. (Author), Gao, J.-H (Author), He, J. (Author), Liang, X. (Author), Liang, Z. (Author), Liu, Y. (Author), Nguchu, B.A (Author), Qiu, B. (Author), Wang, X. (Author), Wang, Y. (Author), Wu, J. (Author), Xia, Y. (Author), Yang, L. (Author), Ying, Y. (Author), Zhang, D. (Author), Zhao, Q. (Author)
Format:	Article
Language:	English
Published:	John Wiley and Sons Inc 2021
Subjects:	aged Aged Aged, 80 and over aging Aging anticoagulant agent antidiabetic agent antihypertensive agent antilipemic agent antithrombocytic agent Article attention Attention axial diffusivity cingulate gyrus cognition computer assisted diagnosis deep learning Deep Learning diagnostic imaging diffusion tensor imaging Diffusion Tensor Imaging diffusion weighted imaging executive function Executive Function female Female fractional anisotropy geriatric patient health care human Humans Image Interpretation, Computer-Assisted inferior longitudinal fasciculus leukoaraiosis Leukoaraiosis major clinical study male Male mean diffusivity microstructural integrity Mini Mental State Examination Montreal cognitive assessment myelinated nerve nerve cell network Nerve Fibers, Myelinated nerve tract Neural Pathways neuroimaging nuclear magnetic resonance imaging pathology physiology priority journal procedures pyramidal tract Pyramidal Tracts radial diffusivity Rey auditory verbal learning test superior longitudinal fasciculus thalamus anterior nucleus tractography trail making test uncinate fasciculus very elderly white matter White Matter white matter hyperintensities
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White matter hyperintensities induce distal deficits in the connected fibers

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