The role of BDNF exon I region methylation in the treatment of depression with sertraline and its clinical diagnostic value

The role of BDNF exon I region methylation in the treatment of depression with sertraline and its clinical diagnostic value

Background: Brain-derived neurotrophic factor (BDNF) is considered to be one of the best candidate genes for depression. However, whether sertraline treatment affects the methylation level of this gene remains unknown. Methods: Fifty-three patients with depression and 51 healthy controls were includ...

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Bibliographic Details
Main Authors: Cheng, J. (Author), Gao, S. (Author), Li, G. (Author), Sun, T. (Author), Xing, Y. (Author), Xu, G. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
5-hydroxytryptamine
adolescent
Adolescent
adult
Adult
aged
Aged
amino acid blood level
antidepressant agent
Antidepressive Agents
Article
BDNF
BDNF gene
BDNF protein, human
biological marker
Biomarkers
blood
blood sampling
brain derived neurotrophic factor
Brain-Derived Neurotrophic Factor
case control study
Case-Control Studies
chemistry
controlled study
depression
Depression
diagnostic value
DNA methylation
DNA Methylation
exon
Exons
female
Female
gene
gene locus
gene methylation
gene sequence
genetic correlation
genetic variation
genetics
genotype
Hamilton Depression Rating Scale
homocysteine
human
Humans
major clinical study
male
Male
middle aged
Middle Aged
Polymorphism, Single Nucleotide
predictive value
receiver operating characteristic
ROC Curve
scoring system
sertraline
Sertraline
single nucleotide polymorphism
young adult
Young Adult
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