Brain-derived neurotrophic factor predominantly regulates the expression of synapse-related genes in the striatum: Insights from in vitro transcriptomics

Brain-derived neurotrophic factor predominantly regulates the expression of synapse-related genes in the striatum: Insights from in vitro transcriptomics

Aim: The striatum, a main component of the basal ganglia, is a critical part of the motor and reward systems of the brain. It consists of GABAergic and cholinergic neurons and receives projections of dopaminergic, glutamatergic, and serotonergic neurons from other brain regions. Brain-derived neurot...

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Bibliographic Details
Main Authors: Adachi, N. (Author), Kawai, A. (Author), Koshimizu, H. (Author), Matsuoka, H. (Author), Miki, T. (Author), Nakajima, Y. (Author), Ohta, K.-I (Author), Ono, J. (Author), Sunagawa, M. (Author), Suzuki, S. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
abrineurin
animal
animal cell
animal experiment
Animals
Apold1
apolipoprotein L
apolipoprotein L domain containing 1
Article
BDNF
brain derived neurotrophic factor
Brain-Derived Neurotrophic Factor
cholinergic synapse
controlled study
corpus striatum
Corpus Striatum
DESeq2
differential expression analysis
differential gene expression
dissociated cell culture
dopaminergic system
embryo
female
GABAergic system
GAGE
gene expression
gene set enrichment analysis
genetics
glutamatergic synapse
in vitro study
male
messenger RNA
metabolism
nerve cell
Neurons
nonhuman
rat
Rats
RNA extraction
RNA sequencing
RNA-Seq
striatum
synapse
synapse vesicle
Synapses
synaptogenesis
transcriptome
Transcriptome
transcriptomics
unclassified drug
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