Synthesized flavanoid-derived ligand reduced dengue virus type-2 replication in vitro

Synthesized flavanoid-derived ligand reduced dengue virus type-2 replication in vitro

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Objective To investigate the antiviral property of a lead ligand, YK51 that was synthesized based on the flavanoid of a natural product toward dengue virus type-2 (DENV2) replication. Methods cRNA was isolated from HepG2 cells inoculated with 1 000 median tissue culture infective dose of DENV2 and t...

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Bibliographic Details
Main Authors: Abd. Rahman, N. (Author), Lee, Y.K (Author), Muhamad, M. (Author), Yusof, R. (Author)
Format: Article
Language:English
Published: Hainan Medical University 2017
Subjects:
actin
animal cell
antiviral activity
Article
BHK cell line
cell structure
concentration response
confocal microscopy
controlled study
Cytoskeletal actin tubulin distribution
Dengue replication
Dengue virus 2
drug synthesis
flavonoid
gene dosage
Hep-G2 cell line
human
human cell
in vitro study
Inhibition assay
inoculation
microtubule
nonhuman
priority journal
protein localization
quantitative analysis
Quantitative RT-PCR
reverse transcription polymerase chain reaction
RNA
RNA isolation
Synthesized derived ligand
tissue culture
tubulin
unclassified drug
virus load
virus replication
yk 51
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