Assessment of antiviral potencies of cannabinoids against SARS-CoV-2 using computational and in vitro approaches

Assessment of antiviral potencies of cannabinoids against SARS-CoV-2 using computational and in vitro approaches

Effective treatment choices to the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are limited because of the absence of effective target-based therapeutics. The main object of the current research was to estimate the antiviral activity of cannabinoids (CBDs) against the human coronavir...

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Bibliographic Details
Main Authors: Cho, K.-H (Author), Choi, P. (Author), Ham, J. (Author), Kim, T. (Author), Lee, J. (Author), Park, J.G (Author), Raj, V. (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2021
Subjects:
3C-like proteinase, SARS-CoV-2
animal cell
antiviral activity
Antiviral Agents
antivirus agent
Article
binding affinity
binding site
biological model
cannabidiol
Cannabidiol
cannabinoid
Cannabinoids
Cannabinols
chemistry
chloroquine
computer model
computer simulation
Computer Simulation
controlled study
Coronavirus 3C Proteases
COVID-19
density functional theory
dose response
dronabinol
Dronabinol
drug absorption
drug determination
drug distribution
drug effect
Drug Evaluation, Preclinical
drug metabolism
drug stability
drug structure
drug therapy
high performance liquid chromatography
human
Humans
IC50
immunofluorescence
In vitro antiviral assay
in vitro study
In Vitro Techniques
ligand
Ligands
lopinavir
Models, Biological
molecular docking
Molecular Docking Simulation
molecular dynamics
Molecular Dynamics Simulation
nonhuman
nuclear magnetic resonance spectroscopy
pandemic
Pandemics
preclinical study
Protease Inhibitors
proteinase inhibitor
remdesivir
SARS-CoV-2
SARS-CoV-2 and Mpro enzyme
Severe acute respiratory syndrome coronavirus 2
Vero cell line
virology
virus cell interaction
virus morphology
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