Chitosan-Carboxymethyl-5-Fluorouracil-Folate Conjugate Particles: Microwave Modulated Uptake by Skin and Melanoma Cells

Chitosan-Carboxymethyl-5-Fluorouracil-Folate Conjugate Particles: Microwave Modulated Uptake by Skin and Melanoma Cells

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5-Fluorouracil delivery profiles in the form of chitosan-folate submicron particles through skin and melanoma cells in vitro were examined using microwaves as the penetration enhancer. The in vivo pharmacokinetic profile of 5-fluorouracil was also determined. Chitosan-carboxymethyl-5-fluorouracil-fo...

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Bibliographic Details
Main Authors: Nawaz, A. (Author), Wong, T.W (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2018
Subjects:
Administration, Cutaneous
animal experiment
antineoplastic activity
antineoplastic agent
area under the curve
Article
carboxymethyl-chitosan
Cell Line, Tumor
cell membrane
cell viability
chemistry
chitosan
Chitosan
chitosan carboxymethyl 5 fluorouracil folate conjugate
chitosan derivative
controlled study
cutaneous drug administration
drug bioavailability
drug delivery system
Drug Delivery Systems
drug effect
drug release
drug retention
fluorouracil
Fluorouracil
fluorouracil derivative
folic acid
Folic Acid
human
Humans
in vitro study
in vivo study
lipid raft
male
maximum plasma concentration
melanoma
Melanoma
melanoma cell
membrane microdomain
Membrane Microdomains
microwave irradiation
microwave radiation
Microwaves
nanoparticle
Nanoparticles
nonhuman
particle size
pathology
pharmacokinetic parameters
plasma concentration-time curve
priority journal
rat
skin
Skin
skin absorption
Skin Absorption
skin cell
Skin Neoplasms
skin tumor
SK-MEL-28 cell line
tumor cell line
unclassified drug
zeta potential
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