Histologic pattern of invasion and epithelial-mesenchymal phenotype predict prognosis in squamous carcinoma of the head and neck

Introduction: Disruption of E-cadherin function and increased expression of vimentin and the transcriptional oncogene, SOX2, are thought to characterize epithelial to mesenchymal transition (EMT) in HNSCC that contributes to invasive and metastatic behavior. To determine if such changes relate to pr...

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Bibliographic Details
Main Authors:	Amlani, L. (Author), Bellile, E. (Author), Donnelly, C.R (Author), Lei, Y.L (Author), McHugh, J.B (Author), Nguyen, A. (Author), Rozek, L. (Author), the Head and Neck SPORE Program (Author), Thomas, D. (Author), Winter, W. (Author), Wolf, G.T (Author)
Format:	Article
Language:	English
Published:	Elsevier Ltd 2018
Subjects:	adult Antigens, CD antineoplastic agent Article Biomarkers, Tumor biopsy Biopsy cadherin Cadherins cancer prognosis cancer survival CD4 antigen CD8 antigen CDH1 protein, human chemoradiotherapy clinical outcome disease free survival Disease-Free Survival E-cadherin epidemiology epithelial mesenchymal transition Epithelial-Mesenchymal Transition female Female follow up Follow-Up Studies Head and neck cancer Head and Neck Neoplasms head and neck squamous cell carcinoma head and neck tumor human Humans immune response immunohistology immunology Kaplan Meier method Kaplan-Meier Estimate leukocyte antigen Lymphocytes, Tumor-Infiltrating major clinical study male Male metabolism middle aged Middle Aged mortality Neoplasm Invasiveness Neoplasm Recurrence, Local overall survival pathology Pattern of invasion priority journal prognosis Prognosis protein expression recurrence free survival SOX2 SOX2 protein, human SOXB1 Transcription Factors Squamous Cell Carcinoma of Head and Neck Survival Tissue Array Analysis tissue microarray transcription factor FOXP3 transcription factor Sox transcription factor Sox2 treatment outcome treatment response tumor associated leukocyte tumor invasion tumor marker tumor recurrence uvomorulin VIM protein, human vimentin Vimentin
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Histologic pattern of invasion and epithelial-mesenchymal phenotype predict prognosis in squamous carcinoma of the head and neck

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