SKA-31, an activator of Ca2+-activated K+ channels, improves cardiovascular function in aging

SKA-31, an activator of Ca2+-activated K+ channels, improves cardiovascular function in aging

Aging represents an independent risk factor for the development of cardiovascular disease, and is associated with complex structural and functional alterations in the vasculature, such as endothelial dysfunction. Small- and intermediate-conductance, Ca2+-activated K+ channels (KCa2.3 and KCa3.1, res...

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Bibliographic Details
Main Authors: Braun, A.P (Author), Fauzi, F.M (Author), Fedak, P.W.M (Author), George, G. (Author), John, C.M (Author), Kendrick, D.J (Author), Khaddaj Mallat, R. (Author), Kim, T. (Author), Mishra, R.C (Author), Singh, V. (Author), Turnbull, J.D (Author), Umeshappa, C.S (Author), Visser, F. (Author), Wulff, H. (Author)
Format: Article
Language:English
Published: Academic Press, 2020
Subjects:
aging
Aging
animal
Animals
arterial pressure
Arterial Pressure
Arteries
benzothiazole derivative
Benzothiazoles
Ca2+-activated K+ channels
calcium activated potassium channel
cell culture
Cells, Cultured
drug effect
heart
Heart
heart stroke volume
Immune system
male
Male
metabolism
naphtho(1,2-d)thiazol-2-ylamine
physiology
Potassium Channels, Calcium-Activated
Rats, Sprague-Dawley
Sprague Dawley rat
Stroke Volume
vasodilatation
Vasodilation
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