Evaluation of Loading Strategies to Improve Tumor Uptake of Gemcitabine in a Murine Orthotopic Bladder Cancer Model Using Ultrasound and Microbubbles

Evaluation of Loading Strategies to Improve Tumor Uptake of Gemcitabine in a Murine Orthotopic Bladder Cancer Model Using Ultrasound and Microbubbles

In this study we compared three different microbubble-based approaches to the delivery of a widely used chemotherapy drug, gemcitabine: (i) co-administration of gemcitabine and microbubbles (Gem+MB); (ii) conjugates of microbubbles and gemcitabine-loaded liposomes (GemlipoMB); and (iii) microbubbles...

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Bibliographic Details
Main Authors: Bau, L. (Author), Browning, R.J (Author), Callan, J.F (Author), Folkes, L. (Author), Gray, M.D (Author), Hampson, A. (Author), Kamila, S. (Author), Kiltie, A.E (Author), McHale, A.P (Author), Ruan, J.-L (Author), Stride, E. (Author), Vojnovic, B. (Author), Yildiz, Y.O (Author)
Format: Article
Language:English
Published: Elsevier Inc. 2021
Subjects:
animal
animal experiment
animal model
animal tissue
Animals
Antimetabolites, Antineoplastic
antineoplastic antimetabolite
apoptosis
Article
Biotinylation
Biotinylations
Bladder cancer
Bladder cancers
bladder tumor
cancer chemotherapy
Cancer models
caspase 3
Cell culture
Cell death
Chemotherapy
circulation time
comparative study
Controlled drug delivery
controlled study
deoxycytidine
Deoxycytidine
disease model
Disease Models, Animal
Diseases
drug blood level
drug delivery system
Drug Delivery Systems
Drug products
drug structure
drug uptake
female
Female
gemcitabine
Gemcitabine
human
human cell
in vitro study
in vivo study
In-vitro
In-vivo
liposome
Liposome
Liposomes
metabolism
Mice
Mice, Nude
microbubble
Micro-bubble
Microbubbles
mouse
muscle invasive bladder cancer
Nanoparticles
nonhuman
nude mouse
Orthotopic
Orthotopic model
priority journal
procedures
protein cleavage
protein expression
pulse rate
RT-112 cell line
Targeted drug delivery
tumor cell culture
Tumor Cells, Cultured
Tumors
Ultrasonic Therapy
Ultrasonics
ultrasound targeted microbubble destruction
ultrasound therapy
Ultrasound-mediated drug delivery
Urinary Bladder Neoplasms
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