In vivo efficacy of tobramycin-loaded synthetic calcium phosphate beads in a rabbit model of staphylococcal osteomyelitis

In vivo efficacy of tobramycin-loaded synthetic calcium phosphate beads in a rabbit model of staphylococcal osteomyelitis

Background: Osteomyelitis is an acute or chronic inflammatory process of the bone following infection with pyogenic organisms like Staphylococcus aureus. Tobramycin (TOB) is a promising aminoglycoside antibiotic used to treat various bacterial infections, including S. aureus. The aim of this study w...

Full description

Bibliographic Details
Main Authors: Abba, Y. (Author), Karunanidhi, A. (Author), Lulu, G.A (Author), Mohamad Yusof, L. (Author), Mohd Fauzi, F. (Author), Othman, F. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd. 2018
Subjects:
adult
animal
animal experiment
animal model
animal tissue
Animals
antibacterial activity
Antibacterial activity
Anti-Bacterial Agents
antiinfective agent
Article
bacterial colonization
bacterial growth
bacterial strain
body weight
calcium phosphate
Calcium phosphate beads
Calcium Phosphates
chemistry
clinical effectiveness
controlled study
devices
disease model
Disease Models, Animal
drug delivery system
Drug Delivery Systems
drug effect
evaluation study
growth, development and aging
histopathology
human
Humans
in vivo study
Leporidae
leukocyte count
male
Male
microbiology
New Zealand White (rabbit)
nonhuman
osteomyelitis
Osteomyelitis
physiology
procedures
Rabbits
Staphylococcal Infections
Staphylococcus aureus
Staphylococcus infection
temperature measurement
tobramycin
Tobramycin
treatment outcome
treatment response
Online Access:View Fulltext in Publisher
View in Scopus

Internet

View Fulltext in Publisher
View in Scopus

Similar Items