The CD14 C-260T single nucleotide polymorphism (SNP) modulates monocyte/macrophage activation in treated HIV-infected individuals

Background: HIV-infected individuals have an increased risk of cardiovascular disease (CVD). T-allele carriers of the CD14 C-260T single-nucleotide polymorphism (SNP) have reported increased expression of the LPS-binding receptor, CD14 and inflammation in the general population. Our aim was to explo...

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Bibliographic Details
Main Authors:	Abdullah, N.K (Author), Kamarulzaman, A. (Author), Kong, Y.Y (Author), Lewin, S.R (Author), Nadarajah, R. (Author), Ponampalavanar, S. (Author), Rajasuriar, R. (Author), Spelman, T. (Author), Yuhana, M.Y (Author)
Format:	Article
Language:	English
Published:	BioMed Central Ltd. 2015
Subjects:	adult Adult aged allele Antigens, CD14 arterial wall thickness Article Atherosclerosis biological marker Biomarkers C reactive protein cardiovascular risk carotid atherosclerosis Carotid intima media thickness Carotid Intima-Media Thickness CD12 C-260T CD14 antigen CD14 gene CD163 antigen cohort analysis Cohort Studies controlled study C-reactive protein female Female Framingham risk score genetic association genetic predisposition Genetic Predisposition to Disease genetic variability genetics genotype heterozygote highly active antiretroviral therapy HIV HIV Infections human human cell Human immunodeficiency virus infection Humans immunomodulation inflammation Inflammation Lipopolysaccharide macrophage activation Macrophage Activation Malaysia male Male metabolism monocyte Monocyte activation Monocytes multivariate analysis Multivariate Analysis Polymorphism, Single Nucleotide protein blood level risk factor Risk Factors single nucleotide polymorphism Soluble CD14 Soluble CD163
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The CD14 C-260T single nucleotide polymorphism (SNP) modulates monocyte/macrophage activation in treated HIV-infected individuals

Internet

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