High resolution melting analysis and detection of Leishmania resistance: the role of multi drug resistance 1 gene

High resolution melting analysis and detection of Leishmania resistance: the role of multi drug resistance 1 gene

Background: Pentavalent antimonial compounds are currently used to treat leishmaniasis and resistance to these drugs is a serious problem. Multidrug resistance protein is an efflux pump of the cell membrane that expels foreign compounds. This study designed to evaluate the mutations in the multi-dru...

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Bibliographic Details
Main Authors: Abadi, M.F.S (Author), Dabiri, S. (Author), Moradabadi, A. (Author), Rad, I. (Author), Rostami, S. (Author), Shojaeepour, S. (Author), Vahidi, R. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
Article
bacterial gene
bacterial strain
controlled study
cutaneous leishmaniasis
DNA extraction
gene identification
gene mutation
gene sequence
genomic DNA
high resolution melting analysis
HRM method
human
human tissue
Leishmania tropica
major clinical study
melting temperature
multidrug resistance
Multi-drug resistance 1 gene
multidrug resistance protein 1
nucleotide
Pentavalent antimonial compounds
sequence analysis
Unresponsive leishmaniasis
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