Ternary copper(II) complex: NCI60 screening, toxicity studies, and evaluation of efficacy in xenograft models of nasopharyngeal carcinoma

Copper(II) ternary complex, [Cu(phen)(C-dmg)(H2O)]NO3 was evaluated against a panel of cell lines, tested for in vivo efficacy in nasopharyngeal carcinoma xenograft models as well as for toxicity in NOD scid gamma mice. The Cu(II) complex displayed broad spectrum cytotoxicity against multiple cancer...

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Bibliographic Details
Main Authors:	Ahmad, M. (Author), Aziz, N.A (Author), Chu, T.-L (Author), Khoo, A.S.-B (Author), Kornain, N.-K.M (Author), Lo, K.-W (Author), Ng, C.-H (Author), Samiulla, D.S (Author), Suhaimi, S.-N (Author)
Format:	Article
Language:	English
Published:	Public Library of Science 2018
Subjects:	animal animal cell animal experiment animal model Animals antineoplastic agent Antineoplastic Agents Article biosynthesis cancer inhibition carcinoma Carcinoma Cell Line, Tumor central nervous system cancer cell line chemistry colon cancer cell line controlled study copper Copper copper complex cytochrome P450 cytochrome P450 1A cytochrome P450 1A2 cytochrome P450 2B6 cytochrome P450 2C19 cytochrome P450 2C8 cytochrome P450 2C9 cytochrome P450 2D6 cytochrome P450 3A cytochrome P450 3A4 Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System cytochrome P450 inhibitor cytotoxicity dose response Dose-Response Relationship, Drug drug effects drug efficacy drug screening enzyme induction Enzyme Induction female Female Hepatocytes in vivo study isoenzyme liver cell lung cancer cell line melanoma cell line metabolism Mice mouse Nasopharyngeal Neoplasms nasopharynx carcinoma nasopharynx tumor nonhuman organometallic compound Organometallic Compounds ovarian cancer cell line pathology prostate cancer cell line rat Rats toxicity testing tumor cell line tumor xenograft Xenograft Model Antitumor Assays
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Ternary copper(II) complex: NCI60 screening, toxicity studies, and evaluation of efficacy in xenograft models of nasopharyngeal carcinoma

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