Modular micro-physiological human tumor/tissue models based on decellularized tissue for improved preclinical testing

Modular micro-physiological human tumor/tissue models based on decellularized tissue for improved preclinical testing

High attrition rates associated with drug testing in 2D cell culture and animal models stress the need for improved modeling of human tumor tissues. In previous studies, our 3D models on a decellularized tissue matrix have shown better predictivity and higher chemoresistance. A single porcine intest...

Full description

Bibliographic Details
Main Authors: Baur, F. (Author), Brähler, C. (Author), Dandekar, G. (Author), Dandekar, T. (Author), Fuchs, M. (Author), Göttlich, C. (Author), Kronenthaler, C. (Author), Kühnemundt, J. (Author), Kunz, M. (Author), Leifeld, H. (Author), Nelke, L.C (Author), Nietzer, S.L (Author), Peindl, M. (Author), Prelog, M. (Author), Scherg, F. (Author), Schmitt, M. (Author), Schmitt, T. (Author), Walles, H. (Author), Wischhusen, J. (Author)
Format: Article
Language:English
Published: ALTEX Edition 2021
Subjects:
4',6 diamidino 2 phenylindole
7 aminodactinomycin
ab16667
ab49496
ab51037
ab6586
ab8601
ab92547
activated leukocyte cell adhesion molecule
additive effect
alcohol
animal experiment
animal model
animal tissue
apoptosis
apoptosis rate
Article
basement membrane
breast cancer
c2562
cancer model
carcinoma cell
caspase 9
CD133 antigen
cell growth
cell invasion
cell migration
cell proliferation
coculture
collagen type 4
colorectal cancer
computer model
controlled study
cytokeratin 18
decellularization
deoxycholate sodium
deoxyribonuclease I
diaminobenzidine
dimethyl sulfoxide
DNA replication
down regulation
drug response
drug screening
endothelium cell
enzyme linked immunosorbent assay
eosin
epithelial cell adhesion molecule
epithelial mesenchymal transition
extracellular matrix
fibroblast
flow cytometry
gefitinib
gene expression
gene ontology
glutaraldehyde
glycolysis
HCC827 cell line
hematoxylin
Hermes antigen
histology
HLA A2 antigen
human
human cell
human tissue
hydrogen peroxide
immunocompetent cell
immunohistochemistry
immunotherapy
in vitro study
intestinal stem cell
Ki 67 antigen
leukemia
lung cancer
m0701
mab4399
MCF-7 cell line
MDA-MB-231 cell line
metformin
microarray analysis
morphogenesis
nonhuman
paraffin embedding
paraformaldehyde
penicillin derivative
peripheral blood mononuclear cell
phosphate buffered saline
pig
platelet endothelial cell adhesion molecule 1
polymerase chain reaction
preclinical study
prediction
pyruvate sodium
receptor type tyrosine protein phosphatase C
RNA isolation
scanning electron microscopy
signal transduction
skin biopsy
streptomycin
SW480 cell line
T lymphocyte
THP-1 cell line
tipifarnib
tissue engineering
tumor microenvironment
TUNEL assay
upregulation
vimentin
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items