Negative interactions determine Clostridioides difficile growth in synthetic human gut communities

Negative interactions determine Clostridioides difficile growth in synthetic human gut communities

Understanding the principles of colonization resistance of the gut microbiome to the pathogen Clostridioides difficile will enable the design of defined bacterial therapeutics. We investigate the ecological principles of community resistance to C. difficile using a synthetic human gut microbiome. Us...

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Bibliographic Details
Main Authors: Amador-Noguez, D. (Author), Clark, R.L (Author), Hromada, S. (Author), Jacobson, T.B (Author), Qian, Y. (Author), Safdar, N. (Author), Venturelli, O.S (Author), Watson, L. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
acidification
article
Bacteria
bacterium
Clostridioides
Clostridioides difficile
Clostridium infection
Clostridium Infections
competition
computational modeling
computer model
ecological interactions
Gastrointestinal Microbiome
gastrointestinal tract
human
Humans
infectious agent
intestine flora
microbiome
nonhuman
pathogen invasion
species richness
systems biology
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