Longitudinal copy number, whole exome and targeted deep sequencing of 'good risk' IGHV-mutated CLL patients with progressive disease

Longitudinal copy number, whole exome and targeted deep sequencing of 'good risk' IGHV-mutated CLL patients with progressive disease

Disease progression in IGHV-M CLL with 'good-risk' cytogenetics is frequently associated with co-evolution of 'poor risk' driver mutations and DNA methylation changes.Drug resistance in IGHV-M CLL may be consequent upon the emergence of an IGHV-U cloneThe biological features of I...

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Main Authors: Rose-Zerilli, Matthew (Author), Gibson, Jane (Author), Wang, Jun (Author), Tapper, Wi (Author), Davis, Zadie (Author), Parker, Helen (Author), Larrayoz, Marta (Author), McCarthy, Helen (Author), Walewska, Renata (Author), Forster, Jade (Author), Gardiner, Anne (Author), Steele, Andrew (Author), Chelala, Claude (Author), Ennis, Sarah (Author), Collins, Andrew (Author), Oakes, Christopher (Author), Oscier, David (Author), Strefford, Jonathan (Author)
Format: Article
Language:English
Published: 2016-06.
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