Synthesis of new isoquinoline-base-oxadiazole derivatives as potent inhibitors of thymidine phosphorylase and molecular docking study

Synthesis of new isoquinoline-base-oxadiazole derivatives as potent inhibitors of thymidine phosphorylase and molecular docking study

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Here in this study regarding the over expression of TP, which causes some physical, mental and socio problems like psoriasis, chronic inflammatory disease, tumor angiogenesis and rheumatoid arthritis etc. By this consideration, the inhibition of this enzyme is vital to secure life from serious threa...

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Bibliographic Details
Main Authors: Ahmed, QU (Author), Rahim, F (Author), Shah, SAA (Author), Taha, M (Author), Wadood, A (Author), Zakaria, ZA (Author), Zaman, K (Author)
Format: Article
Language:English
Published: 2019
Subjects:
ACETYLCHOLINESTERASE
ALPHA-GLUCOSIDASE SYNTHESIS
ANALOGS
BETA-GLUCURONIDASE
BIOLOGICAL EVALUATION
CELL GROWTH-FACTOR
IN-VITRO EVALUATION
THIOSEMICARBAZIDES
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