Empagliflozin and Kidney Function Decline in Patients with Type 2 Diabetes: A Slope Analysis from the EMPA-REG OUTCOME Trial

Empagliflozin and Kidney Function Decline in Patients with Type 2 Diabetes: A Slope Analysis from the EMPA-REG OUTCOME Trial

Background Empagliflozin slowed the progression of CKD in patients with type 2 diabetes and cardiovascular disease in the EMPA-REG OUTCOME Trial. In a prespecified statistical approach, we assessed treatment differences in kidney function by analyzing slopes of eGFR changes.

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Main Authors: EMPA-REG OUTCOME Investigators, Abu Hassan, M (Author), Adawi, F (Author), Adojaan, B (Author), Agafyina, A (Author), Aguilar-Salinas, C (Author), Agung, P (Author), Ahmad, NN (Author), Aiello, A (Author), Aizenberg, D (Author), Ajani, D (Author), Aloi, J (Author), Al-Windy, N (Author), Alzohaili, O (Author), Amod, A (Author), Andersen, J (Author), Anderson, M (Author), Andrade, L (Author), Anspach, R (Author), Antoli, A (Author), Antonypillai, C (Author), Aquitania, G (Author), Aravind, S (Author), Arca, M (Author), Arena, C (Author), Arif, A (Author), Aronoff, S (Author), Artola, S (Author), Arutyunov, G (Author), Aure, P (Author), Austin, B (Author), Avramidis, I (Author), Awad, A (Author), Ayoub, J (Author), Badgandi, M (Author), Balasko, A (Author), Balic, S (Author), Ball, E (Author), Bantwal, G (Author), Barager, W (Author), Baranowski, M (Author), Barbarash, O (Author), Barbarich, V (Author), Barbonta, D (Author), Barker, B (Author), Bashkin, A (Author), Bayly, K (Author), Belenkiy, D (Author), Benatar, J (Author), Benhalima, K (Author), Benroubi, M (Author), Bergenstal, R (Author), Bergman, B (Author), Berlingieri, J (Author), Bertolami, M (Author), Berz, A (Author), Betti, R (Author), Bittar, N (Author), Blakney, E (Author), Blaze, K (Author), Blignaut, S (Author), Boesgaard, TW (Author), Bononi, P (Author), Borges, J (Author), Boscia, J (Author), Boucher, P (Author), Bousboulas, S (Author), Bowden, R (Author), Boyarkin, M (Author), Brandon, D (Author), Bratcher, C (Author), Bravo, LG (Author), Brazao, M (Author), Bressler, P (Author), Breton, C (Author), Bretton, E (Author), Brito, M (Author), Brockmyre, A (Author), Broedl, UC (Author), Brusco, O (Author), Bucci, M (Author), Bulugahapitiya, D (Author), Burgess, L (Author), Burr, R (Author), Burtchuladze, T (Author), Butler, M (Author), Buynak, R (Author), Bystrova, A (Author), Cahill, T (Author), Calabro, P (Author), Calderon, JU (Author), Caldwell, I (Author), Camafort, M (Author), Capiau, L (Author), Castro, M (Author), Catrinoiu, D (Author), Cefalu, W (Author), Chachati, A (Author), Chacra, A (Author), Chan, Y (Author), Chandramouli, A (Author), Chang, H (Author), Chang, K (Author), Chappell, D (Author), Chauhan, A (Author), Chaykin, L (Author), Chee, K (Author), Chehayeb, R (Author), Chen, J (Author), Cherlin, R (Author), Chiang, C (Author), Choksi, M (Author), Choukroun, G (Author), Christensen, P (Author), Christensen, T (Author), Chumakova, G (Author), Cignarelli, M (Author), Clavel, S (Author), Clayton, D (Author), Colfer, H (Author), Colivicchi, F (Author), Colombo, H (Author), Concha, YR (Author), Connery, L (Author), Cosma, D (Author), Couffinhal, T (Author), Courreges, J (Author), Crisan, C (Author), Cruz, H (Author), Cuddihy, R (Author), Curtis, C (Author), Daugenet, C (Author), de Jong, A (Author), De La Rosa, R (Author), De Loredo, L (Author), De Los Santos, G (Author), de Teresa, L (Author), Deerochanawong, C (Author), Dekelver, P (Author), del Canizo, F 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Format: Article
Language:English
Published: 2018
Subjects:
chronic kidney disease
COTRANSPORTER 2 INHIBITION
diabetes mellitus
END-POINTS
ESTABLISHED CARDIOVASCULAR-DISEASE
GFR DECLINE
GLOMERULAR-FILTRATION-RATE
MECHANISMS
MELLITUS
randomized controlled trials
SAFETY
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