Time-resolved multimodal analysis of Src Homology 2 (SH2) domain binding in signaling by receptor tyrosine kinases

by Oh, Dongmyung, Ogiue-Ikeda, Mari, Machida, Kazuya, Yu, Ji, Jadwin, Joshua A., Curran, Timothy G., White, Forest M., Mayer, Bruce J., Jia, Lin, Ph. D. Massachusetts Institute of Technology
Published 2016

Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment

by Gomez, James E, Kaufmann-Malaga, Benjamin B, Wivagg, Carl N, Kim, Peter B, Silvis, Melanie R, Renedo, Nikolai, Ioerger, Thomas R, Ahmad, Rushdy, Livny, Jonathan, Fishbein, Skye, Hung, Deborah T, Carr, Steven A
Published 2017

Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer

by Sayin, Volkan I, LeBoeuf, Sarah E, Singh, Simranjit X, Biancur, Douglas, Guzelhan, Betul S, Alvarez, Samantha W, Wu, Warren L, Karakousi, Triantafyllia R, Zavitsanou, Anastasia Maria, Ubriaco, Julian, Karagiannis, Dimitris, Morris, Patrick J, Thomas, Craig J, Possemato, Richard, Papagiannakopoulos, Thales, Davidson, Shawn M, Muir, Alexander, Vander Heiden, Matthew G.
Published 2018

Spatial signals link exit from mitosis to spindle position

by Falk, Jill, Tsuchiya, Dai, Verdaasdonk, Jolien, Lacefield, Soni, Bloom, Kerry, Amon, Angelika B
Published 2016

Synergistic interactions with PI3K inhibition that induce apoptosis

by Zwang, Yaara, Chen, Casandra, Rinne, Mikael L, Doench, John G, Piccioni, Federica, Tan, Li, Huang, Hai-Tsang, Wang, Jinhua, Ham, Young Jin, O'Connell, Joyce, Bhola, Patrick, Doshi, Mihir, Whitman, Matthew, Letai, Anthony, Root, David E, Gray, Nathanael, Hahn, William C, Jonas, Oliver H., Langer, Robert S, Cima, Michael J.
Published 2017

Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability

by Sullivan, Mark Robert, Danai, Laura V, Lewis, Caroline A, Chan, Sze Ham, Gui, Dan Yi, Kunchok, Tenzin, Dennstedt, Emily A, Vander Heiden, Matthew G., Muir, Alexander
Published 2021

Dynamic control of Hsf1 during heat shock by a chaperone switch and phosphorylation

by Zheng, Xu, Krakowiak, Joanna, Patel, Nikit, Beyzavi, Ali, Ezike, Jideofor, Khalil, Ahmad S, Pincus, David
Published 2017

Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition

by Lewis, Caroline A, Muir, Alexander, Danai, Laura V, Gui, Dan Yi, Waingarten, Chiara Y., Vander Heiden, Matthew G.
Published 2018

Exploration of CTCF post-translation modifications uncovers Serine-224 phosphorylation by PLK1 at pericentric regions during the G2/M transition

by Del Rosario, Amanda M, White, Forest M.
Published 2020

Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway

by Depoil, David, Martinelli, Roberta, Judokusumo, Edward, Carmona, Guillaume, Kam, Lance C., Carman, Christopher V., Burkhardt, Janis K., Dustin, Michael L., Gertler, Frank, Kumari, Sudha, Irvine, Darrell J
Published 2015

Mammalian cell growth dynamics in mitosis

by Miettinen, Teemu P, Kang, Joon Ho, Yang, Lucy F., Manalis, Scott R
Published 2020

Hypoxia-inducible factor cell non-autonomously regulates C. elegans stress responses and behavior via a nuclear receptor

by Pender, Corinne Lenore, Horvitz, Howard Robert
Published 2020

A role for PVRL4-driven cell-cell interactions in tumorigenesis

by Pallasch, Christian, Braun, Christian Joerg, Hemann, Michael, Pavlova, Natalya N., Elia, Andrew E. H., Westbrook, Thomas F., Elledge, Stephen J.
Published 2014

Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters

by Naba, Alexandra, Clauser, Karl R., Carr, Steven A., Lamar, John, Hynes, Richard O
Published 2014

Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs

by Van de Kooij, Bert, Creixell Morera, Pau, Van Vlimmeren, Anne Elise, Joughin, Brian Alan, Yaffe, Michael B
Published 2020

Viral factors in influenza pandemic risk assessment

by Lipsitch, Marc, Barclay, Wendy, Raman, Rahul, Russell, Charles J, Belser, Jessica A, Cobey, Sarah, Kasson, Peter M, Lloyd-Smith, James O, Maurer-Stroh, Sebastian, Riley, Steven, Beauchemin, Catherine AA, Bedford, Trevor, Friedrich, Thomas C, Handel, Andreas, Herfst, Sander, Murcia, Pablo R, Roche, Benjamin, Wilke, Claus O, Russell, Colin A
Published 2017

Alternative RNA splicing in the endothelium mediated in part by Rbfox2 regulates the arterial response to low flow

by Kimble, Amy L., Murphy, Patrick A., Butty, Vincent L. G., Boutz, Paul, Begum, Shahinoor, Sharp, Phillip A., Burge, Christopher B., Hynes, Richard O.
Published 2018

Enhanced ER proteostasis and temperature differentially impact the mutational tolerance of influenza hemagglutinin

by Phillips, Angela Marie, Gonzalez, Luna O., Butty, Vincent L G, Shoulders, Matthew D.
Published 2020

Chemical perturbation of an intrinsically disordered region of TFIID distinguishes two modes of transcription initiation

by Zhang, Zhengjian, Boskovic, Zarko, Hu, Wenxin, Inouye, Carla, Kim, Han-Je, Tjian, Robert, Hussain, Mahmud M., Abole, A. Katherine, Doud, Mary K., Lewis, Timothy A., Koehler, Angela Nicole, Schreiber, Stuart L.
Published 2015

Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates

by Wyant, Gregory A, Abu-Remaileh, Monther, Sabatini, David M.
Published 2020