controlled study Article 253 male 196 human 194 female 168 Humans 158 adult 136 nonhuman 136 Male 107 major clinical study 101 animal experiment 98 Animals 97 Female 92 mouse 90 animal 89 metabolism 85 unclassified drug 83 middle aged 75 animal model 69 Middle Aged 61 aged 61 animal tissue 57 Mice 55 genetics 55 Adult 54 human cell 50 protein expression 50 animal cell 49 priority journal 44 hemoglobin A1c 43