protein stability Article 21 chemistry 16 controlled study 16 human 14 Humans 12 metabolism 12 Protein Stability 11 genetics 11 nonhuman 11 protein structure 10 protein binding 9 protein function 9 unclassified drug 9 Models, Molecular 8 amino acid sequence 8 protein domain 8 molecular model 7 Protein Binding 6 Amino Acid Sequence 5 Mutation 5 binding site 5 human cell 5 in vitro study 5 mutation 5 protein analysis 5 Cell Line, Tumor 4 Computational Biology 4 Male 4 X ray crystallography 4