genetic association 113 human 111 Article 98 Humans 88 controlled study 78 genetics 78 female 76 male 74 adult 66 Female 61 Male 59 major clinical study 55 single nucleotide polymorphism 51 genotype 42 middle aged 38 Polymorphism, Single Nucleotide 37 gene 37 Middle Aged 36 gene frequency 35 Genetic Predisposition to Disease 33 case control study 32 genetic predisposition 32 Adult 31 genetic variability 31 Case-Control Studies 30 aged 28 gene expression 26 metabolism 25 nonhuman 25 Aged 23