Article 111 human 105 controlled study 96 Humans 89 reverse transcription polymerase chain reaction 82 male 60 nonhuman 60 genetics 59 female 58 adult 54 real time reverse transcription polymerase chain reaction 51 unclassified drug 44 gene expression 41 Male 40 Female 38 middle aged 35 metabolism 34 Middle Aged 33 major clinical study 31 SARS-CoV-2 30 human cell 30 protein expression 30 COVID-19 29 coronavirus disease 2019 28 animal experiment 26 upregulation 25 Western blotting 24 mouse 23 sensitivity and specificity 23 Animals 22