Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts

Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts

Abstract Background Recent studies indicated that seeded fibril formation and toxicity of α-synuclein (α-syn) play a main role in the pathogenesis of certain diseases including Parkinson’s disease (PD), multiple system atrophy, and dementia with Lewy bodies. Therefore, examination of compounds that...

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Bibliographic Details
Main Authors: Mustafa T. Ardah, Simona S. Ghanem, Sara A. Abdulla, Guohua Lv, Mohamed M. Emara, Katerina E. Paleologou, Nishant N. Vaikath, Jia-Hong Lu, Min Li, Konstantinos Vekrellis, David Eliezer, Omar M. A. El-Agnaf
Format: Article
Language:English
Published: BMC 2020-03-01
Series:BMC Complementary Medicine and Therapies
Subjects:
α-Synuclein
Parkinson’s disease
Seeded fibril formation
Amyloid fibrils
Salvianolic acid B
Dihydromyricetin
Online Access:http://link.springer.com/article/10.1186/s12906-020-2849-1

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http://link.springer.com/article/10.1186/s12906-020-2849-1

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