The Pioglitazone Trek via Human PPAR Gamma: From Discovery to a Medicine at the FDA and Beyond

The Pioglitazone Trek via Human PPAR Gamma: From Discovery to a Medicine at the FDA and Beyond

For almost two decades, pioglitazone has been prescribed primarily to prevent and treat insulin resistance in some type 2 diabetic patients. In this review, we trace the path to discovery of pioglitazone as a thiazolidinedione compound, the glitazone tracks through the regulatory agencies, the trek...

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Bibliographic Details
Main Authors: Pallavi R. Devchand, Tianyun Liu, Russ B. Altman, Garret A. FitzGerald, Eric E. Schadt
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Pharmacology
Subjects:
pioglitazone
PPAR gamma
protein–drug interactions
nuclear receptor
glitazone medications
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01093/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01093/full

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