Clinical Variability of SYNJ1-Associated Early-Onset Parkinsonism

Clinical Variability of SYNJ1-Associated Early-Onset Parkinsonism

Autosomal recessive early-onset parkinsonism is clinically and genetically heterogeneous. Mutations of three genes, PRKN, PINK1, and DJ-1 cause pure phenotypes usually characterized by levodopa-responsive Parkinson's disease. By contrast, mutations of other genes, including ATP13A2, PLA2G6, FBX...

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Bibliographic Details
Main Authors: Suzanne Lesage, Graziella Mangone, Christelle Tesson, Hélène Bertrand, Mustapha Benmahdjoub, Selma Kesraoui, Mohamed Arezki, Andrew Singleton, Jean-Christophe Corvol, Alexis Brice
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Neurology
Subjects:
Parkinson's disease
SYNJ1
autosomal recessive inheritance
early-onset parkinsonism
atypical Parkinson's disease
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2021.648457/full

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https://www.frontiersin.org/articles/10.3389/fneur.2021.648457/full

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