TOM40 mediates mitochondrial dysfunction induced by α-synuclein accumulation in Parkinson's disease.

TOM40 mediates mitochondrial dysfunction induced by α-synuclein accumulation in Parkinson's disease.

Alpha-synuclein (α-Syn) accumulation/aggregation and mitochondrial dysfunction play prominent roles in the pathology of Parkinson's disease. We have previously shown that postmortem human dopaminergic neurons from PD brains accumulate high levels of mitochondrial DNA (mtDNA) deletions. We now a...

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Bibliographic Details
Main Authors: Andreas Bender, Paula Desplats, Brian Spencer, Edward Rockenstein, Anthony Adame, Matthias Elstner, Christoph Laub, Sarina Mueller, Andrew O Koob, Michael Mante, Emily Pham, Thomas Klopstock, Eliezer Masliah
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3633917?pdf=render

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http://europepmc.org/articles/PMC3633917?pdf=render

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