Ultra-deep massively parallel sequencing with unique molecular identifier tagging achieves comparable performance to droplet digital PCR for detection and quantification of circulating tumor DNA from lung cancer patients.

Ultra-deep massively parallel sequencing with unique molecular identifier tagging achieves comparable performance to droplet digital PCR for detection and quantification of circulating tumor DNA from lung cancer patients.

The identification and quantification of actionable mutations are of critical importance for effective genotype-directed therapies, prognosis and drug response monitoring in patients with non-small-cell lung cancer (NSCLC). Although tumor tissue biopsy remains the gold standard for diagnosis of NSCL...

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Bibliographic Details
Main Authors: Le Son Tran, Hong-Anh Thi Pham, Vu-Uyen Tran, Thanh-Truong Tran, Anh-Thu Huynh Dang, Dinh-Thong Le, Son-Lam Nguyen, Ngoc-Vu Nguyen, Trieu-Vu Nguyen, Binh Thanh Vo, Hong-Thuy Thi Dao, Nguyen Huu Nguyen, Tam Huu Tran, Chu Van Nguyen, Phuong Cam Pham, Anh Tuan Dang-Mai, Thien Kim Dinh-Nguyen, Van Hieu Phan, Thanh-Thuy Thi Do, Kiet Truong Dinh, Han Ngoc Do, Minh-Duy Phan, Hoa Giang, Hoai-Nghia Nguyen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0226193

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https://doi.org/10.1371/journal.pone.0226193

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