Corynoxine Protects Dopaminergic Neurons Through Inducing Autophagy and Diminishing Neuroinflammation in Rotenone-Induced Animal Models of Parkinson’s Disease

Corynoxine Protects Dopaminergic Neurons Through Inducing Autophagy and Diminishing Neuroinflammation in Rotenone-Induced Animal Models of Parkinson’s Disease

Recent studies have shown that impairment of autophagy is related to the pathogenesis of Parkinson’s disease (PD), and small molecular autophagy enhancers are suggested to be potential drug candidates against PD. Previous studies identified corynoxine (Cory), an oxindole alkaloid isolated from the C...

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Bibliographic Details
Main Authors: Leilei Chen, Yujv Huang, Xing Yu, Jiahong Lu, Wenting Jia, Juxian Song, Liangfeng Liu, Youcui Wang, Yingyu Huang, Junxia Xie, Min Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
parkinson’s disease
corynoxine
rotenone
autophagy
α-synuclein
neuroinflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.642900/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.642900/full

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