Developmental deficits and staging of dynamics of age associated Alzheimer’s disease neurodegeneration and neuronal loss in subjects with Down syndrome

Developmental deficits and staging of dynamics of age associated Alzheimer’s disease neurodegeneration and neuronal loss in subjects with Down syndrome

The increased life expectancy of individuals with Down syndrome (DS) is associated with increased prevalence of trisomy 21–linked early-onset Alzheimer’s disease (EOAD) and dementia. The aims of this study of 14 brain regions including the entorhinal cortex, hippocampus, basal ganglia, and cerebellu...

Full description

Bibliographic Details
Main Authors: Bobrowicz, T.W (Author), de Leon, M. (Author), Flory, M. (Author), Kuchna, I. (Author), Lai, F. (Author), Ma, S.Y (Author), Nowicki, K. (Author), Silverman, W.P (Author), Wegiel, J. (Author), Wisniewski, T. (Author), Zhong, N. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
adult
Adult
aged
Aged
aging
Aging
Alzheimer disease
Alzheimer Disease
Alzheimer’s disease
brain
Brain
Clinicopathological staging
complication
Developmental neuronal deficits
Down syndrome
Down Syndrome
female
Female
human
Humans
Lewy bodies
male
Male
middle aged
Middle Aged
nerve cell
nerve degeneration
Nerve Degeneration
Neurofibrillary degeneration
Neuronal loss
Neurons
pathology
Stereology
TDP-43 neurodegeneration
β-amyloidosis
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items