Search Results - Stephen Neidle

Stephen Neidle

Professor Stephen Neidle is a British X-ray crystallographer, chemist and drug designer working at the UCL School of Pharmacy. His area of scientific research has been in nucleic acid structure and recognition, and the research topic of quadruplexes. Provided by Wikipedia
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  1. 1

    Structured Waters Mediate Small Molecule Binding to G-Quadruplex Nucleic Acids by Stephen Neidle

    Published in Pharmaceuticals (2021-12-01)
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  2. 2

    The Targeting of Quadruplex Nucleic Acids in Human Cancers by Stephen Neidle

    Published in Proceedings (2019-08-01)
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  3. 3

    A Phenotypic Approach to the Discovery of Potent G-Quadruplex Targeted Drugs by Stephen Neidle

    Published in Molecules (2024-08-01)
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  4. 4

    On Water Arrangements in Right- and Left-Handed DNA Structures by Liliya A. Yatsunyk, Stephen Neidle

    Published in Molecules (2024-01-01)
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  5. 5

    A G-Quadruplex-Binding Small Molecule and the HDAC Inhibitor SAHA (Vorinostat) Act Synergistically in Gemcitabine-Sensitive and Resistant Pancreatic Cancer Cells by Ahmed Abdullah Ahmed, Stephen Neidle

    Published in Molecules (2020-11-01)
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  6. 6

    Cellular adaptations impact the biological activity of naphthalene diimide G-quadruplex ligands in ALT-positive osteosarcoma cells by Joanna Bidzinska, Lorenzo Di Pietro, Eisa Naghshineh, Cecilia Pandini, Filippo Doria, Nadia Zaffaroni, Paolo Gandellini, Stephen Neidle, Marco Folini

    Published in Cell Death and Disease (2025-08-01)
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  7. 7

    The Potent G-Quadruplex-Binding Compound QN-302 Downregulates S100P Gene Expression in Cells and in an In Vivo Model of Pancreatic Cancer by Ahmed A. Ahmed, William Greenhalf, Daniel H. Palmer, Nicole Williams, Jenny Worthington, Tariq Arshad, Shozeb Haider, Effrosyni Alexandrou, Dilek Guneri, Zoe A. E. Waller, Stephen Neidle

    Published in Molecules (2023-03-01)
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  8. 8

    Structure–activity relationships for the G-quadruplex-targeting experimental drug QN-302 and two analogues probed with comparative transcriptome profiling and molecular modeling by Ahmed Abdullah Ahmed, Shuang Chen, Maria Roman-Escorza, Richard Angell, Sally Oxenford, Matthew McConville, Naomi Barton, Mihiro Sunose, Dan Neidle, Shozeb Haider, Tariq Arshad, Stephen Neidle

    Published in Scientific Reports (2024-02-01)
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  9. 9

    G‐quadruplex‐binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo by Roberto Simone, Rubika Balendra, Thomas G Moens, Elisavet Preza, Katherine M Wilson, Amanda Heslegrave, Nathan S Woodling, Teresa Niccoli, Javier Gilbert‐Jaramillo, Samir Abdelkarim, Emma L Clayton, Mica Clarke, Marie‐Therese Konrad, Andrew J Nicoll, Jamie S Mitchell, Andrea Calvo, Adriano Chio, Henry Houlden, James M Polke, Mohamed A Ismail, Chad E Stephens, Tam Vo, Abdelbasset A Farahat, W David Wilson, David W Boykin, Henrik Zetterberg, Linda Partridge, Selina Wray, Gary Parkinson, Stephen Neidle, Rickie Patani, Pietro Fratta, Adrian M Isaacs

    Published in EMBO Molecular Medicine (2017-11-01)
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