Structured Waters Mediate Small Molecule Binding to G-Quadruplex Nucleic Acids

The role of G-quadruplexes in human cancers is increasingly well-defined. Accordingly, G-quadruplexes can be suitable drug targets and many small molecules have been identified to date as G-quadruplex binders, some using computer-based design methods and co-crystal structures. The role of bound wate...

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Bibliographic Details

Published in:	Pharmaceuticals
Main Author:	Stephen Neidle
Format:	Article
Language:	English
Published:	MDPI AG 2021-12-01
Subjects:	G-quadruplex ligands naphthalene diimides acridines crystal structures water clusters
Online Access:	https://www.mdpi.com/1424-8247/15/1/7