Mechanism of active component β-sitosterol from Myristica fragrans inducing apoptosis in bladder cancer cells via regulating the BCL-2/BAX/caspase-3 pathway

BackgroundNutmeg (Myristica fragrans) has been traditionally used in herbal medicine, but its potential anti-cancer effects remain largely unexplored. This study aimed to investigate the molecular mechanisms of nutmeg against bladder cancer through an integrated strategy combining network pharmacolo...

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Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Yongkang Zhu, Zhao Tang, Zhaoyue Lu, Dongyang Gao, Hao Pan, Haozhe Jiang, Zhen Zhang, Huiqing Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-11-01
Subjects:	Myristica fragrans bladder cancer network pharmacology β-sitosterol apoptosis
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1698721/full