Mcm5 mutation leads to silencing of Stat1-bcl2 which accelerating apoptosis of immature T lymphocytes with DNA damage

Abstract Mutation in genes involved in DNA replication continuously disrupt DNA replication and give rise to genomic instability, a critical driver of oncogenesis. To prevent leukemia, immature T lymphocytes with genomic instability often undergo rapid cell death during development. However, the mec...

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Bibliographic Details

Published in:	Cell Death and Disease
Main Authors:	Min Liu, Yuanyuan Li, Zhilin Deng, Ke Zhang, Shuying Huang, Jiamin Xia, Yi Feng, Yundan Liang, Chengfu Sun, Xindong Liu, Shurong Li, Bingyin Su, Yong dong, Sizhou Huang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2025-02-01
Online Access:	https://doi.org/10.1038/s41419-025-07392-8