Current practice and recommendations for advancing how human variability and susceptibility are considered in chemical risk assessment

Abstract A key element of risk assessment is accounting for the full range of variability in response to environmental exposures. Default dose-response methods typically assume a 10-fold difference in response to chemical exposures between average (healthy) and susceptible humans, despite evidence o...

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Bibliographic Details

Published in:	Environmental Health
Main Authors:	Julia R. Varshavsky, Swati D. G. Rayasam, Jennifer B. Sass, Daniel A. Axelrad, Carl F. Cranor, Dale Hattis, Russ Hauser, Patricia D. Koman, Emily C. Marquez, Rachel Morello-Frosch, Catherine Oksas, Sharyle Patton, Joshua F. Robinson, Sheela Sathyanarayana, Peggy M. Shepard, Tracey J. Woodruff
Format:	Article
Language:	English
Published:	BMC 2023-01-01
Subjects:	Adjustment factors Chemicals Cumulative risk Environmental justice EPA NAMs
Online Access:	https://doi.org/10.1186/s12940-022-00940-1