The ZZ domain of HERC2 is a receptor of arginylated substrates

Abstract The E3 ubiquitin ligase HERC2 has been linked to neurological diseases and cancer, however it remains a poorly characterized human protein. Here, we show that the ZZ domain of HERC2 (HERC2ZZ) recognizes a mimetic of the Nt-R cargo degradation signal. NMR titration experiments and mutagenesi...

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發表在:	Scientific Reports
Main Authors:	Adam H. Tencer, Jiuyang Liu, Jing Zhu, Nathaniel T. Burkholder, Yi Zhang, Wenwen Wu, Brian D. Strahl, Tomohiko Ohta, Tatiana G. Kutateladze
格式:	Article
語言:	英语
出版:	Nature Portfolio 2022-04-01
在線閱讀:	https://doi.org/10.1038/s41598-022-10119-w