Ceramide synthesis inhibitors prevent lipid-induced insulin resistance through the DAG-PKCε-insulin receptorT1150 phosphorylation pathway

Summary: Inhibition of the ceramide synthetic pathway with myriocin or an antisense oligonucleotide (ASO) targeting dihydroceramide desaturase (DES1) both improved hepatic insulin sensitivity in rats fed either a saturated or unsaturated fat diet and was associated with reductions in both hepatic ce...

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Bibliographic Details

Published in:	Cell Reports
Main Authors:	Weiwei Xu, Dongyan Zhang, Yumin Ma, Rafael C. Gaspar, Mario Kahn, Ali Nasiri, Sue Murray, Varman T. Samuel, Gerald I. Shulman
Format:	Article
Language:	English
Published:	Elsevier 2024-10-01
Subjects:	CP: Metabolism CP: Molecular biology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124724010970