In vitro CRISPR screening uncovers CRTC3 as a regulator of IFN-γ-induced ferroptosis of hepatocellular carcinoma

Abstract Interferon-gamma (IFN-γ) exerts anti-tumor effects by inducing ferroptosis. Based on CRISPR/Cas9 knockout screening targeting genome-wide protein encoding genes in HepG2 and SK-Hep-1 cell lines, we found that cAMP response element-binding protein (CREB) regulated transcription coactivator 3...

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Bibliographic Details

Published in:	Cell Death Discovery
Main Authors:	Li Li, Tao Xing, Yiran Chen, Weiran Xu, Bo Fan, Gaoda Ju, Jing Zhao, Li Lin, Cihui Yan, Jun Liang, Xiubao Ren
Format:	Article
Language:	English
Published:	Nature Publishing Group 2023-09-01
Online Access:	https://doi.org/10.1038/s41420-023-01630-8