Gasdermin D-mediated keratinocyte pyroptosis as a key step in psoriasis pathogenesis

Abstract Gasdermin D (GSDMD)-mediated pyroptosis has a significant pro-inflammation characteristic due to dramatic secretion of pro-inflammatory substances. However, its role remains unclear in psoriasis as one chronic inflammatory skin disorder with high prevalence. We found that N-terminal GSDMD (...

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Bibliographic Details

Published in:	Cell Death and Disease
Main Authors:	Ni Lian, Yujie Chen, Sihan Chen, Ying Zhang, Hao Chen, Yong Yang, Heng Gu, Qing Chen, Min Li, Xu Chen
Format:	Article
Language:	English
Published:	Nature Publishing Group 2023-09-01
Online Access:	https://doi.org/10.1038/s41419-023-06094-3